puzzle picture
1802: Sketchbook Symmetric Trimer Design: 70 Residues
Status: Closed

Summary

Name: 1802: Sketchbook Symmetric Trimer Design: 70 Residues
Status: Closed
Created: 02/20/2020
Points: 100
Expired: 02/27/2020 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C3 symmetry, with three symmetric chains. This a Sketchbook puzzle with a Move Limit of 250 moves! After that, you will be unable to improve your solution, but you can restart the puzzle to reset your move count! The Move Limit is meant to encourage players to try lots of different folds, and we hope this will increase the diversity of player solutions. This puzzle is also a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Go Science18,465100
2Anthropic Dreams18,28563
3Beta Folders18,26137
4Void Crushers18,24621
5Contenders17,84611

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1ZeroLeak7 16 1 Go Science18,377100
2Bruno Kestemont 1 2 Go Science18,30595
3mirp 7 14 Go Science18,30191
4hpaege 127 35  18,29286
5grogar7 89 4 Anthropic Dreams18,28582


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Comments

bkoep's picture
User offline. Last seen 8 hours 9 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2100)
Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 72 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Move Limit
Scores become invalid after 250 moves. Players are encouraged to restart the puzzle and try a new fold!

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OSX
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons