puzzle picture
1799: Sketchbook Symmetric Trimer Design: 90 Residues
Status: Closed


Name: 1799: Sketchbook Symmetric Trimer Design: 90 Residues
Status: Closed
Created: 02/13/2020
Points: 100
Expired: 02/20/2020 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C3 symmetry, with three symmetric chains. This a Sketchbook puzzle with a Move Limit of 250 moves! After that, you will be unable to improve your solution, but you can restart the puzzle to reset your move count! The Move Limit is meant to encourage players to try lots of different folds, and we hope this will increase the diversity of player solutions. This puzzle is also a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

Top Groups

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2Anthropic Dreams21,29568
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1NinjaGreg 11 16 Go Science21,587100
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5ZeroLeak7 7 1 Go Science21,13881

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crowns's picture
User offline. Last seen 11 hours 32 min ago. Offline
Joined: 02/20/2020
Groups: None
How I played this puzzle

That's how I earned 10000 points:
1.Make all the chain into helix and then make it ideal.
2.Pull the chain into whatever shape.
3.Link the chain with its two mirrors and itself with as many rubber bands as possible in whatever ways and then wiggle to let the chain fold into a weird knot.
4.Click mutate and wait a few minutes.
5.Clear all the rubber bands and re-add rubber bands elsewhere, and repeat the steps above. Also try out "auto structures".
I'm new to this game. I don't know how such a random-generated protein will be used. If you have better ways please tell me.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons