(Sat, 02/08/2020 - 08:53 | 5 comments)
Designing Proteins With Sequences Like Text Messages:
|Opened on:||Saturday, February 8, 2020 - 08:53|
|Last modified:||Sunday, February 9, 2020 - 21:17|
The other night, I was talking with some of my teammates about a new type of Design Puzzle that might be fun around the Holidays, like past Snowflake Design Puzzles: https://fold.it/portal/node/996492 Puzzle 825 https://fold.it/portal/node/996573 Puzzle 825 https://fold.it/portal/node/2001693 Puzzle 1174 https://fold.it/portal/node/2001765 Puzzle 1174 https://fold.it/portal/node/2001775 Puzzle 1174 The goal is to design a protein with a single-letter-code amino acid sequence that is meaningful, like a Tweet or short text message. This means the text message can only use the 20 letters for the 20 different amino acids (all letters from a-z except b j o u x and z). Some examples are below: catchascatchcanastitchintimesavesnine thisgameisverytrickychallenginghardandaddictive ihaveaflamingheartcantgetmyfill anappleadaykeepsamanhealthywealthyandwise apennysavedisapennyearned thecatsinthecradle theladyinredisdancingwithme myfairladytheraininspainfallsmainlyintheplains thisgamehasmanysmartandniceplayersandadmins etcetceteraandtherestandetalallmeanthesamething It would be interesting to see how the above examples would fold. Which parts would form helices, sheets, and loops? Which would have good cores or hydrogen bond networks? Which could form dimers?