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1790: Symmetric Trimer Design
Status: Closed


Name: 1790: Symmetric Trimer Design
Status: Closed
Created: 01/23/2020
Points: 100
Expired: 01/30/2020 - 23:00
Difficulty: Intermediate
Description: Design a symmetric trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective so that no more than 50% of residues may form helices. We're taking a short break from H-bond Networks, but we have a new (optional) challenge for Foldit players! The starting structure includes several helices and sheets placed in a suggested arrangement, similar to a TIM barrel (but with 9 strands instead of 8). This is a hypothetical fold that nobody has been able to design yet, but we think Foldit players may have some ideas! Note that the started arrangement is only a rough placement, we expect players will have to do some considerable refolding to create a high-scoring design. For such a fold to work, it's important that the sheets of one subunit will need to pair with the symmetric sheets on either side, so that the entire barrel forms a continuous and circular hydrogen-bonded sheet!
Categories: Design, Overall, Symmetry

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bkoep's picture
User offline. Last seen 5 hours 35 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Core Existence: Monomer (max +2100)
Ensures that at least 21 residues are buried in the core of the monomer unit.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

Joined: 03/20/2012
Groups: None


Joined: 10/30/2012
Groups: Beta Folders
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lost a couple of folds in auto-save ether

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