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1781: Poly-Proline Helix Design: Round 6
Status: Closed

Summary

Name: 1781: Poly-Proline Helix Design: Round 6
Status: Closed
Created: 01/02/2020
Points: 100
Expired: 01/09/2020 - 23:00
Difficulty: Intermediate
Description: This is the sixth puzzle in the poly-proline helix design series! The starting structure is an 80 reside protein with a 5 residue helix, and all residues are mutable. However we have also increased the reference weight of proline from 16.4 to 50.0 to incentivize keeping proline part of the final design. There were some designs from the previous puzzle that satisfied a good fraction of the oxygens and nitrogens on the helix backbone, and we hope to see that continue. Hydrogen bonds are visible by selecting 'Show advanced GUI' in General Options in the Menu tab, and then selecting 'Show bonds (loop)' and 'Show bondable atoms' in the View tab. Happy Folding!
Categories: Design, Overall

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Comments

neilpg628's picture
User offline. Last seen 9 hours 5 min ago. Offline
Joined: 08/01/2019
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Objectives

Residue Count (max +100)
Penalizes a residue count above 80 by 20 Foldit points per additional residue. The count is capped at 85.

grogar7's picture
User offline. Last seen 3 hours 44 min ago. Offline
Joined: 10/03/2011
mutable poly-proline helix

Why are the prolines on the frozen backbone mutable?

neilpg628's picture
User offline. Last seen 9 hours 5 min ago. Offline
Joined: 08/01/2019
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mutable poly-proline helix

Good question!

A poly-proline helix doesn't have to be made entirely of proline. Any set of residues that adopt the appropriate dihedral angles can be classified as a poly-proline helix. Proline is simply one of the few amino acids that can easily do so.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons