1739: Aflatoxin Challenge: Round 13

Status: Closed

Summary

Name:	1739: Aflatoxin Challenge: Round 13
Status:	Closed
Created:	09/30/2019
Points:	100
Expired:	10/14/2019 - 23:00
Difficulty:	Intermediate
Description:	The Aflatoxin Challenge is back! The Siegel Lab has found a new enzyme scaffold that is better suited to degrade the aflatoxin molecule, and they're asking Foldit players to redesign the enzyme so that it can bind aflatoxin more strongly! Players may insert up to 10 extra residues into two designable loops, at a cost of 20 points per residue. Players may also mutate the sidechains at positions 122 and 123, where the backbone is fixed. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are two loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand! This is the 13th round of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories:	Design, Overall

Top Groups

Rank	Group	Score	Points
1	Contenders	10,141	100
2	Gargleblasters	10,032	77
3	Beta Folders	10,015	58
4	Go Science	9,974	43
5	L'Alliance Francophone	9,969	31

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Top Evolvers

Rank	Player	Group	Score	Points
1	Blipperman 18 29	Gargleblasters	10,032	100
2	ManVsYard 29 285	Gargleblasters	10,023	97
3	LociOiling 7 1	Beta Folders	10,015	94
4	Bruno Kestemont 2 3	Go Science	9,974	91
5	christioanchauvin 98 43	L'Alliance Francophone	9,969	88

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Top Soloists

Rank	Player	Group	Score	Points
1	Bletchley Park 15 26	Contenders	10,141	100
2	Enzyme 149 13788	Gargleblasters	10,031	97
3	LociOiling 7 1	Beta Folders	10,015	94
4	retiredmichael 132 316	Beta Folders	9,938	91
5	Phyx 40 8	Go Science	9,931	88

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Comments

Mon, 09/30/2019 - 23:37

NinjaGreg 26 9

Offline

Joined: 05/21/2010

Groups: Go Science

You might want to reconsider your release sequence

If you prepare the server database, then publicize it to the clients, then list it here, people couldn't download it from here before you were ready for it. Just sayin'.

Tue, 10/01/2019 - 00:06

bkoep 149 2966

Offline

Joined: 11/15/2012

Groups: Foldit Staff

Access before 23:00?

Hmm, all of that should have happened simultaneously at 23:00. Were you able to see this puzzle page before it was visible in the client?

Tue, 10/01/2019 - 01:37

LociOiling 7 1

Offline

Joined: 12/27/2012

Groups: Beta Folders

Puzzles appear first on the web...

Recently at least, puzzles are visible on the website before they show up in the game.

Someone thought the delay was exactly one hour, so possibly a time zone issue.

Some have also figured out there's download link on each puzzle page, a workaround for those who are in a hurry.

Tue, 10/01/2019 - 02:31

bkoep 149 2966

Offline

Joined: 11/15/2012

Groups: Foldit Staff

Possibly delayed client

Hmm, I wonder if the client is delayed for some reason. The next time we post a puzzle, I'll watch the server a little more closely and see if I can figure out what's going on.

Thu, 10/03/2019 - 00:18

spvincent 67 35

Offline

Joined: 12/07/2007

Groups: Contenders

The delay seems to be exactly

The delay seems to be exactly one hour in length. For example, the notification that the recent trimer puzzle had expired came at 5.00pm PST.

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