puzzle picture
1738b: IL-7R Binder Redesign: Round 17
Status: Closed

Summary

Name: 1738b: IL-7R Binder Redesign: Round 17
Status: Closed
Created: 09/29/2019
Points: 100
Expired: 10/03/2019 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle replaces Puzzle 1738, which had errors with the frozen binding helices. Unfortunately, players will not be able to load solutions from Puzzle 1738.

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues between the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the 17th puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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1Gargleblasters11,858100
2Beta Folders11,83770
3Anthropic Dreams11,81847
4Go Science11,81130
5Contenders11,77119

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Comments

bkoep's picture
User offline. Last seen 7 hours 34 min ago. Offline
Joined: 11/15/2012
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Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +400)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons