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1728: IL-7R Binder Redesign: Round 12
Status: Closed


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spvincent's picture
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Joined: 12/07/2007
Groups: Contenders
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LociOiling's picture
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Joined: 12/27/2012
Groups: Beta Folders
no objectives details

The official details about the objectives for this puzzle are missing. Unofficially, here are the objectives from the previous round, which seem to be the same:

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons