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1643: Unsolved De-novo Freestyle 146: Symmetric Dimer
Status: Closed


Name: 1643: Unsolved De-novo Freestyle 146: Symmetric Dimer
Status: Closed
Created: 02/28/2019
Points: 100
Expired: 03/07/2019 - 23:00
Difficulty: Intermediate
Description: This is a follow-up to Puzzle 1634: De-novo Freestyle 146,now with C2 symmetry. This protein was originally designed by a Foldit player as a symmetric dimer. In Puzzle 1634, we challenged the Foldit community to try and predict how the design might fold as a single, monomeric chain. Now we want to see if Foldit players can predict how the original protein was designed to fold and bind to itself with C2 symmetry. Players may load in solutions from Puzzle 1634. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

Categories: Overall, Prediction, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons