Sulfonamides are broken in drug puzzles

Case number:845799-2005202
Opened by:JellyJump
Opened on:Friday, May 11, 2018 - 01:05
Last modified:Monday, May 14, 2018 - 03:55

attempting to add this group to something you are working on results in a "NOT CHEMICALLY FEASIBLE" error

(Fri, 05/11/2018 - 01:05  |  3 comments)

Joined: 12/27/2012

I was able to get the double bonds to the sulfur, but it is kind of tricky.

See the long explanation here:

Basically, add the sulfur. Convert the sulfur's hydrogen to oxygen. Select the sulfur and the oxygen, convert to a double bond. You get another hydrogen, convert it to oxygen, and convert to a double bond. You get yet another hydrogen, which you can convert to nitrogen. Then you're pretty much home free.

You can also first add a carbon and the oxygens, then switch the carbon to sulfur and make the double bonds.

It's not clear how flexible the process is. I didn't find a way to convert my existing TPV to double bonds. I think it would require deleting a lot of it and rebuilding, but not sure.

I was able to get the structure below by adding on the starting structure of 1519.

And as you noted, you can't add an image on the initial feedback, but you can always reply. Just another little thing we live with.

Joined: 12/27/2012

Actually, you can't add an *attachment* to an initial feedback, so no log.txt unless you just do a pastebin or add a comment to the initial feedback.

Adding an image works just fine on feedback and forum posts. Each image gets its own page, a "node" on the website. You can even comment on images, and your comment can include images....

The "plus sign" icon at the lower left of the textbox kicks off the process of adding an image.

See adding images to feedback and forum posts for obsessive detail on how to add images.

One more little problem is that the "Preview" button on a feedback comment doesn't work.

Joined: 12/27/2012

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