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1463: Classroom Puzzle: HIV RNA
Status: Closed

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Susume's picture
User offline. Last seen 5 hours 53 min ago. Offline
Joined: 10/02/2011
nucleotide sequence

The sequence of nucleotides (sidechains) for this puzzle is:
GGCAGAUCUGAGCCUGGGAGCUCUCUGCC

Susume's picture
User offline. Last seen 5 hours 53 min ago. Offline
Joined: 10/02/2011
random stuff for players

To see hydrogen bonds, turn on show bonds (non-protein) in view menu.

In lua, when using structure.GetAminoAcid(n) on an RNA molecule, foldit returns a 2-letter abbreviation for base n ("ra", "rc", "rg", or "ru").

Wikipedia has a page on secondary structure of RNA, with a few pictures of shapes that RNA can make:
https://en.wikipedia.org/wiki/Nucleic_acid_secondary_structure

More pics of shapes RNA can make - scroll down to the "secondary structure" section: http://www.sivabio.50webs.com/nucleicacidstructure.htm

Susume's picture
User offline. Last seen 5 hours 53 min ago. Offline
Joined: 10/02/2011
Need more tools

We really need a way to straighten out the backbone when it gets twisted (wiggle twists it a LOT when we use bands to move things around). No tweak, no remix, no rebuild, no cutting - it's very hard to recover from twisting!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons