1455: Aflatoxin Challenge: Round 4 with Insertions

Summary

Name:

Status:

Closed

Created:

11/29/2017

Points:

100

Expired:

12/13/2017 - 23:00

Difficulty:

Intermediate

Description:

This is the fourth puzzle of our Aflatoxin Challenge; now players may insert and delete residues in solutions from the previous Round 3 puzzle. Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Players may add up to 20 additional residues within these loops, at a cost of 16 points per residue. Players may load in solutions from Puzzle 1450.

This puzzle is part of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.

Categories:

Design, Overall

Rank

Group

Score

Points

Anthropic Dreams

23,106

100

23,100

23,053

23,042

23,016

Rank

Player

Group

Score

Points

Galaxie 1 3

Anthropic Dreams

23,093

100

23,071

23,053

23,053

retiredmichael 46 1458

Beta Folders

23,046

Rank

Player

Group

Score

Points

tokens 46 1458

Anthropic Dreams

23,106

100

23,100

23,048

23,036

retiredmichael 46 1458

Beta Folders

23,027

Sun, 12/03/2017 - 09:23

Bruno Kestemont 3 2

Offline

Joined: 09/24/2012

Groups: Go Science

No choice

I didn't want to play this puzzle but now that I finished puzzle 1454, there is no choice left.

Please give us at least 3 puzzles to play so that we have some choice.

Mon, 12/04/2017 - 20:46

Bruno Kestemont 3 2

Offline

Joined: 09/24/2012

Groups: Go Science

thanks

we got a new one

Fri, 12/08/2017 - 15:41

Susume 46 201

Offline

Joined: 10/02/2011

Groups: Anthropic Dreams

Video with suggestions

I did a stream on Twitch yesterday which is available as a video at www.twitch.tv/Susume2 . It gives several different ideas of ways to modify the enzyme. It's a long video, but you can click the gear icon at the bottom right and set the speed to play faster.

Tue, 12/12/2017 - 23:43

jeff101 25 65

Offline

Joined: 04/20/2012

Groups: Go Science

Aflatoxin Round 5:

What will happen when Puzzle 1455 ends?
Will there be a blog/video/chat giving
us feedback about Rounds 1-4 before
Aflatoxin Round 5 is posted? Will
Round 5 be like Rounds 1 & 3 but with
a 3rd orientation for the Aflatoxin?

Wed, 12/13/2017 - 17:58

jeff101 25 65

Offline

Joined: 04/20/2012

Groups: Go Science

Aflatoxin Round 5:

Will Round 5 be like Round 2, where we can import solutions from Rounds 1 & 2? Will Round 5 be a multi-start puzzle, using a handful of the Foldit Team's favorite solutions from Rounds 1 & 2 as starting structures to choose from?

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