puzzle picture
1416: Large Monomer Design
Status: Closed

Summary

Name: 1416: Large Monomer Design
Status: Closed
Created: 08/10/2017
Points: 100
Expired: 08/18/2017 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 85-105 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Beta Folders10,702100
2Anthropic Dreams10,67163
3Contenders10,66837
4Go Science10,57921
5Gargleblasters10,53911

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1LociOiling 2 2 Beta Folders10,702100
2markm457 80 1 Anthropic Dreams10,67196
3gitwut 26 17 Contenders10,66892
4dcrwheeler 80 7  10,58087
5isaksson 32 30 Go Science10,57283


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Comments

bkoep's picture
User offline. Last seen 17 hours 59 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

gitwut's picture
User offline. Last seen 36 min 43 sec ago. Offline
Joined: 05/18/2012
Groups: Contenders
Wrong description

The puzzle descriptions are for the previous small monomer puzzle in both the client puzzle menu and here. The comment (85-105) appears correct.

bkoep's picture
User offline. Last seen 17 hours 59 min ago. Offline
Joined: 11/15/2012
Groups: None
Good catch!

I've amended the puzzle description.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons