puzzle picture
Beginner Puzzle (<150): Docking Design
Status: Closed

Summary

Name: Beginner Puzzle (<150): Docking Design
Status: Closed
Created: 01/27/2014
Points: 100
Expired: 05/18/2017 - 23:00
Difficulty: Beginner
Description: We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:
- Lonely Sheets,
- Lock and Lower,
- Rebuild,
- Structure and Rebuild,
- Movin' Along,
- Control over Clashing,
- Intro to Design,
- Swappin' Sidechains,
- Mass Mutate,
- Insertion and Deletion

before starting this puzzle.

Categories: Beginner

Top Groups

RankGroupScorePoints
1STME 52408,916100
2SFASU_BIO448/5488,89082
3Anthropic Dreams8,88066
4Structural-Bioinformatics8,85453
5D001x Med Chem MOOC8,85342

Top Soloists

RankPlayerGroupScorePoints
1anthion 42 26  8,962100
2WalkerP 80 1356  8,95599
3paroos 80 2058  8,92698
4Lord_FoxxDrake 80 2058 STME 52408,91697
5bigcode 80 2058  8,91096


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons