puzzle picture
1357: Electron Density Practice: Trypsin Inhibitor
Status: Closed

Summary

Name: 1357: Electron Density Practice: Trypsin Inhibitor
Status: Closed
Created: 03/24/2017
Points: 100
Expired: 03/31/2017 - 23:00
Difficulty: Intermediate
Description: This puzzle is meant for Foldit players to practice folding a protein with an electron density map. This electron density map was generated from x-ray diffraction at a resolution of 1.5 Å, and was published in 1983. The protein is an inhibitor of trypsin, an enzyme whose role it is to break down other proteins. This protein includes six cysteines that oxidize to form three disulfide bonds. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

Sequence:
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
Categories: Electron Density, Overall, Prediction

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1Go Science12,348100
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons