puzzle picture
1290: 90 Residue Monomer Design: No Rebuilding!
Status: Closed

Summary

Name: 1290: 90 Residue Monomer Design: No Rebuilding!
Status: Closed
Created: 09/28/2016
Points: 100
Expired: 10/06/2016 - 23:00
Difficulty: Intermediate
Description: This puzzle is similar to recent design puzzles, but we'd like players to avoid using the Rebuild tool. We suspect that the Rebuild tool has been introducing some problematic backbones into Foldit player designs, so the Rebuild tool has been deactivated in this puzzle. In most cases, the Remix tool can be used as an alternative to Rebuild. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 2 days 14 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

actiasluna's picture
User offline. Last seen 7 hours 28 min ago. Offline
Joined: 03/05/2015
Groups: Gargleblasters
This one is crashing the client for me continually

It works for a while then the client just disappears without its customary mac crash report window appearing. Have already put this in feedback. Not having trouble with other puzzles (except for a crash with 1289 and remix). First time was with a LUA recipe, second time with another LUA recipe.

actiasluna's picture
User offline. Last seen 7 hours 28 min ago. Offline
Joined: 03/05/2015
Groups: Gargleblasters
additionally>- I took the most recent update before this started

I took the most recent update before this started

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons