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1285: 75 Residue Monomer Design: No Rebuild!
Status: Closed

Summary

Name: 1285: 75 Residue Monomer Design: No Rebuild!
Status: Closed
Created: 09/15/2016
Points: 100
Expired: 09/22/2016 - 23:00
Difficulty: Intermediate
Description: This puzzle is similar to recent design puzzles, but we'd like players to avoid using the Rebuild tool. We suspect that the Rebuild tool has been introducing some problematic backbones into Foldit player designs, so the Rebuild tool has been deactivated in this puzzle. In most cases, the Remix tool can be used as an alternative to Rebuild. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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1Contenders10,429100
2Anthropic Dreams10,35865
3Beta Folders10,35141
4Go Science10,34224
5Gargleblasters10,32514

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Comments

bkoep's picture
User offline. Last seen 42 min 41 sec ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

jamiexq's picture
User offline. Last seen 1 week 2 days ago. Offline
Joined: 07/31/2011
no rebuild okay - but why no cut??

why is cut disabled too?

jamiexq's picture
User offline. Last seen 1 week 2 days ago. Offline
Joined: 07/31/2011
and wiggle too?

wiggle doesn't seem to work either

Joined: 10/30/2012
Groups: Beta Folders
cut is only broken in main

cut is only broken in main

Susume's picture
User offline. Last seen 2 hours 30 min ago. Offline
Joined: 10/02/2011
To clarify, cut is disabled

To clarify, cut is disabled in original interface, but not in selection interface. This is true in both main build and devprev build (which are currently the same).

To make a cut in selection interface, select two adjacent segments, and a pair of scissors will appear with a C by it - click that to cut.

jamiexq's picture
User offline. Last seen 1 week 2 days ago. Offline
Joined: 07/31/2011
Main vs devprev

Well foldit doesn't work at all for me in devprev - they turned sound back on in devprev and windows 10 laptops will not work in devprev now

Joined: 10/23/2014
Groups: Contenders
Recipes

Additionally some recipes don't work at all with this puzzle.

Joined: 09/24/2012
Groups: Go Science
Some rebuild recipes I suppose

Recipes with rebuilds do not work well but do not crash. Rebuild simply do nothing.
Recipes with cuts do not crash and work.

Joined: 04/24/2014
Groups: None
Cut update

Cut fix should be in the next release, as far as I've been informed. As always, stay tuned to any release notes to be sure.

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