puzzle picture
1191: 65 Residue Symmetric Tetramer: H-Bond Networks
Status: Closed

Summary

Name: 1191: 65 Residue Symmetric Tetramer: H-Bond Networks
Status: Closed
Created: 02/07/2016
Points: 100
Expired: 02/13/2016 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C4 symmetry, with four symmetric chains. The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than six inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Comments

bkoep's picture
User offline. Last seen 7 hours 11 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to 8 hydrogen bonds may span all interfaces. In addition, at least 75% of all polar atoms in a network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 19 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 96 residues are buried in the core of the entire complex (including the interface between monomer units).

Joined: 10/30/2012
Groups: Beta Folders
serine down the middle

seems this config. lends itself to serine bonding to each other. had other types bonded early but scripts changed them, wondering if this is just a glitch or its an OK arrangement.

Joined: 04/10/2015
Groups: Beta Folders
3d simmetry?

Just curious.. is it posible to get a puzzle with tetragonal simmetry instead of c4? not all the starting pieces on the same plane and making a Regular Tetrahedron

In order to get a more 3d / globular and non-parallel piece?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons