puzzle picture
1187: 60 Residue Symmetric Trimer: H-Bond Networks
Status: Closed

Summary

Name: 1187: 60 Residue Symmetric Trimer: H-Bond Networks
Status: Closed
Created: 01/28/2016
Points: 100
Expired: 02/04/2016 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C3 symmetry, with three symmetric chains. The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than six inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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1Anthropic Dreams12,706100
2Contenders12,61380
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5L'Alliance Francophone12,42637

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Comments

bkoep's picture
User offline. Last seen 2 days 22 hours ago. Offline
Joined: 11/15/2012
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to 6 hydrogen bonds may span all interfaces. In addition, at least 75% of all polar atoms in a network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 66 residues are buried in the core of the entire complex (including the interface between monomer units).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons