puzzle picture
1179: 70 Residue Symmetric Dimer Design: H-Bond Networks
Status: Closed

Summary

Name: 1179: 70 Residue Symmetric Dimer Design: H-Bond Networks
Status: Closed
Created: 01/07/2016
Points: 100
Expired: 01/14/2016 - 23:00
Difficulty: Intermediate
Description: In this symmetric design puzzle, we're requiring a few more residues to buried in the whole complex (either within the monomer unit or at the interface). The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than four inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Comments

bkoep's picture
User offline. Last seen 2 days 22 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to 4 hydrogen bonds may span the dimer interface. In addition, at least 75% of all polar atoms in a network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 60 residues are buried in the core of the entire complex (including the interface between monomer units).

Joined: 10/30/2012
Groups: Beta Folders
how many networks score? if

how many networks score?
if its only 1 can you let us know

Joined: 10/30/2012
Groups: Beta Folders
OK now figured it out

OK now figured it out

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons