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1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes
Status: Closed


Name: 1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes
Status: Closed
Created: 12/23/2015
Points: 100
Expired: 01/07/2016 - 23:00
Difficulty: Intermediate
Description: This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes the H-bond Network Filter, but requires that networks are at least 75% satisfied! See the puzzle comments for more details. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. This puzzle will remain open for two weeks.

BONUS: It's winter here in Seattle, but we still haven't seen any snow! Submit your best "protein snowflake" using the Upload for Scientists button and the Foldit team will post their favorite snowflakes on the blog! Check out previous Foldit protein snowflakes here!
Categories: Design, Overall, Symmetry

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bkoep's picture
User offline. Last seen 39 min 30 sec ago. Offline
Joined: 11/15/2012
Groups: None

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-12 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 168 residues are buried in the core of the entire complex (including the interface between monomer units).

reefyrob's picture
User offline. Last seen 17 hours 28 min ago. Offline
Joined: 02/08/2012
Groups: Beta Folders
H-Bond score

It would have been nice to know that the allowed max score for H-Bonds is 1200pts

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons