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1147: 75 Residue Symmetric Dimer Design: Limited HBonds
Status: Closed


Name: 1147: 75 Residue Symmetric Dimer Design: Limited HBonds
Status: Closed
Created: 10/10/2015
Points: 0
Expired: 10/18/2015 - 23:00
Difficulty: Intermediate
Description: Note: Due to a bug with the HBNet filter, this puzzle has been closed and reposted as Puzzle 1147b with a modified filter.

In this puzzle, the bonus for Hbond networks has been increased, but only Hbond networks that are at least 75% satisfied will be rewarded. Furthermore, no more than three inter-molecular Hbonds may contribute to each network! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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bkoep's picture
User offline. Last seen 18 hours 29 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-3 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 62 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Joined: 04/28/2015
Groups: Go Science
max inter hbc APPCRASH

max inter hbc

Joined: 10/23/2014
Groups: Contenders
Unable to play

When I try to open the puzzle I get the error message "Unused key 'max_inter_hbs'." After closing the error box the screen remains the same.

Joined: 04/19/2011
Unable to play

Same problem as Tom Taylor has. (I have the latest client)

jamiexq's picture
User offline. Last seen 4 days 22 hours ago. Offline
Joined: 07/31/2011
can't open puzzle

getting same error - windows 7 latest main client

Joined: 09/24/2012
Groups: Go Science
ok in devprev only

Same to me. I then loaded devprev and it worked.
Could you consider giving us more time related to the time when main would be adapted to this puzzle.

Joined: 09/24/2012
Groups: Go Science

But the devprev crashes when I try to "open and share solution".

Joined: 11/18/2012
Groups: None
Also unable to play

Same problem as TomTaylor:
Error message reads: Unused key 'max_inter_hbs'.

Closing the error message leaves me with a black foldit screen and the words No Tool in the upper left.

Joined: 06/06/2013
Groups: Gargleblasters
too big for my machine

I know scientists are interested in some of these larger puzzles. My machine can't handle something this size, particularly with another large puzzle open at the same time. I can only have one large puzzle client open at a time.
Is there a way to make these puzzles smaller? otherwise, I have to keep leaving the puzzles unopened and feel like I will be behind the learning curve

bkoep's picture
User offline. Last seen 18 hours 29 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Thanks for the feedback!

Sorry for the loading hiccup, everyone! This appears to be a problem specific to Foldit for Windows.

We've closed this puzzle and reposted it as Puzzle 1147b, which should be fine for all clients. Players will be able to load solutions into the reposted puzzle.

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