1137: Two-component Abeta binder design
|Name:||1137: Two-component Abeta binder design|
|Expired:||09/27/2015 - 23:00|
|Description:||Note: The expiration date for this puzzle has been extended one week, to 09/27/2015 - 23:00.
This is another puzzle in which we ask you to design a protein that can bind the Abeta peptide, the aggregation of which causes Alzheimer's disease. The hope is that by designing something to bind it up, we'll be able to block its toxicity and halt Alzheimer's disease progression. This time, we're giving you eight different starting points for design, each with a different pattern of disulfide bonds, and each with two distinct halves (which we might ultimately mix-and-match). We'd like nice, well-folded designs with well-packed hydrophobic cores, lots of hydrogen bonds networks on the surface, and no voids. (You can turn on the display of voids in the core in the display options to help you eliminate these.) The loops in the starting conformation are so-so, so you can keep these or redesign them. The Remix tool is available for your use in this puzzle. Regarding the helices and sheets, we'd like you to keep the overall topology of the starting structure, but there are no constraints, so you can move the backbone quite a bit in this puzzle.
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