puzzle picture
1128: 70 Residue Symmetric Dimer Design: Satisfied H-bonds
Status: Closed

Summary

Name: 1128: 70 Residue Symmetric Dimer Design: Satisfied H-bonds
Status: Closed
Created: 08/19/2015
Points: 100
Expired: 08/26/2015 - 23:00
Difficulty: Intermediate
Description: Players will need the latest update to play this puzzle! This puzzle is very similar to previous H-bond network puzzles, though the HBNet filter has been slightly tweaked. In this puzzle, the bonus for H-bond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Comments

bkoep's picture
User offline. Last seen 4 hours 1 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Joined: 10/30/2012
Groups: Beta Folders
scores and bonding seem to be

scores and bonding seem to be elusive in the same structure

Joined: 10/30/2012
Groups: Beta Folders
shared a couple with

shared a couple with scientists, might help figure out the scoring issue
best is 355 hbond 12500 on total with -300 on the complex score

bkoep's picture
User offline. Last seen 4 hours 1 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Thanks retiredmichael!

I'll take a look.

Joined: 04/10/2015
Groups: Beta Folders
More interfase

Is it posible to get a puzzle with a more stringent interfase requirement? For example a dimer with Core Complex- 2 Core Monomer > 14-17 segments 20%-25% of the total size (70 on this one)

Or even better a trimmer with Core Complex- 3 Core Monomer > 14-17 segments 20%-25% of the total size (70 on this one)

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