puzzle picture
1087: Hydrogen Bond Network Filter
Status: Closed

Summary

Name: 1087: Hydrogen Bond Network Filter
Status: Closed
Created: 05/14/2015
Points: 0
Expired: 05/20/2015 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle has been taken down and will be re-posted at a later date. This is our first puzzle featuring the new Hydrogen Bond Network filter. Hydrogen bond networks are sets of hydrogen bonds which span across multiple residues. HBond networks are important for our symmetric designs because they allow us to form interfaces between the symmetric copies, without making those interfaces too hydrophobic. In this puzzle, we've given you a fixed backbone that can make a number of HBond networks - and we've given you a starter network as an example. Mutate the sequence to form HBonds between the Red and Blue polar atoms on the sidechains. Be sure to check out the recent blog post for more information!
Categories: Design, Overall, Symmetry

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Comments

jflat06's picture
User offline. Last seen 6 hours 47 min ago. Offline
Joined: 09/29/2010
Groups: Window Group
Be sure to check out the new blog post here:
Joined: 10/30/2012
Groups: Beta Folders
when i run a spreadsheet with

when i run a spreadsheet with the segment scoring, i get a lot of low scores especially side chain and clashing. these are on the h bond segments,

early days for this kind of puzzle, thinking a slight reduction in the bonus might be a good thing to try

Joined: 09/21/2011
Groups: Void Crushers
scoring problems

With the scoring problems with this puzzle, it should be retracted until this is fixed.

Joined: 10/30/2012
Groups: Beta Folders
have to agree with Timo, not

have to agree with Timo, not ready for prime time

Joined: 10/30/2012
Groups: Beta Folders
enough already, pull this

enough already, pull this thing

Joined: 04/19/2011
the scoring is increasingly annoying

Should be better re-post it, after fixed...

Joined: 10/30/2012
Groups: Beta Folders
on another note, something

on another note, something that would allow us to show only side chains selected, something to reduce the visual clutter

jflat06's picture
User offline. Last seen 6 hours 47 min ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

I've taken the puzzle down to investigate the scoring issues. It will be posted at a later date with the ability to load your solutions.

Skippysk8s's picture
User offline. Last seen 1 day 14 hours ago. Offline
Joined: 06/06/2013
Groups: Gargleblasters
scoring issues

not fixed from dev prev. I agree with Michael, Timo and O Seki To San. please put us out of our misery and just call it a big dev prev
I still like the graphics, but not enough to be this aggravated about the scoring craziness
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons