Case number:845813-2000692
Topic:Game: Tools
Opened by:eusair
Opened on:Thursday, May 7, 2015 - 22:24
Last modified:Friday, September 4, 2015 - 19:38

we can cut our proteins. i would like to be able to splice them...

imagine any design puzzle where loops connect helices/sheets to one another. you spent all kinds of time building your protein and now, in tweaking it, you wonder if it might be better if a particular loop connected elsewhere nearby. for example:

a protein consists of 2 sheets and 1 helix; a loop connects the sheets on one end; a loop connects one of the sheets to the helix on the other end, thus the SS order is sheet, loop, sheet, loop, helix. atm, you have to rebuild nearly the whole protein just to reposition a loop so that the new SS order is sheet, loop, helix, loop, sheet.

- this would result in the renumbering of some of the segments in the protein, but so what...the game/player just needs to make sure the protein has one beginning and one end.

(Thu, 05/07/2015 - 22:24  |  2 comments)

jflat06's picture
User offline. Last seen 11 hours 51 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

This is a feature that I really want to add, but unfortunately it is very difficult to implement (I have tried before). I hope that we'll get it eventually, but it wont happen any time soon.

jeff101's picture
User offline. Last seen 13 hours 3 min ago. Offline
Joined: 04/20/2012
Groups: Go Science

The Recipe shiftit0 (http://fold.it/portal/recipe/101321)
is a step towards making a splice function in Foldit.
Please try it and e-mail me what you think of it.



Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons