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1052: 80 Residue Symmetric Trimer Design
Status: Closed


Name: 1052: 80 Residue Symmetric Trimer Design
Status: Closed
Created: 02/13/2015
Points: 100
Expired: 02/21/2015 - 17:00
Difficulty: Intermediate
Description: This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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bkoep's picture
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Joined: 11/15/2012
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 27% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 32% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

jeff101's picture
User offline. Last seen 8 hours 46 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Does this puzzle crash Foldit?

This puzzle sounds like the devprev BETA Symmetry Debugging puzzle (http://fold.it/portal/node/1998494). If you can find a simple and repeatable way to make Foldit crash on this puzzle, please let the Foldit team know about it.

See http://fold.it/portal/node/2000404 for more info.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons