|
1043: 55 Residue Symmetric Hexamer Design
Status: Closed
|
Summary
| Name: |
1043: 55 Residue Symmetric Hexamer Design |
| Status: |
Closed |
| Created: |
01/28/2015 |
| Points: |
100 |
| Expired: |
02/04/2015 - 20:00 |
| Difficulty: |
Intermediate |
| Description: |
This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions! |
| Categories: | Design, Overall, Symmetry |
|---|
Top Groups
Top Evolvers
Top Soloists
Need this puzzle? Log in to download.
Comments
Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.
Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).
Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!
Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.