Fri, 12/05/2014 - 10:49
#2
results from design puzzles?
there have been a lot design puzzles but there don't seem to have been any successful ones.
Thu, 12/11/2014 - 07:45
#3
Slow and steady
We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.
Fri, 12/05/2014 - 11:23
#4
glycine in a loop is getting a penalty?
it is actually facing internally towards another hydro and is loosing points. Not 'on the surface' at all.
Thu, 12/11/2014 - 07:47
#5
Fixed
This looks like a slip up in the filter setup for this specific puzzle. Should be fixed in future puzzles.
Thanks for the feedback!
Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.
Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.