1021: 65 Residue Monomer Design: SS Design

Summary

Name:

Status:

Closed

Created:

12/02/2014

Points:

100

Expired:

12/09/2014 - 23:00

Difficulty:

Intermediate

Description:

In this puzzle, the SS Design filter also considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Categories:

Design, Overall

Rank

Group

Score

Points

Anthropic Dreams

10,123

100

10,085

10,034

10,006

9,995

Rank

Player

Group

Score

Points

Galaxie 5 9

Anthropic Dreams

10,123

100

10,123

10,123

10,122

10,085

Rank

Player

Group

Score

Points

MurloW 89 2865

Anthropic Dreams

10,120

100

10,061

10,034

10,033

retiredmichael 89 1773

Beta Folders

10,025

Tue, 12/02/2014 - 23:53

bkoep 89 941

Offline

Joined: 11/15/2012

Groups: Foldit Staff

Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Fri, 12/05/2014 - 10:49

spmm 89 2865

Offline

Joined: 08/05/2010

Groups: Void Crushers

results from design puzzles?

there have been a lot design puzzles but there don't seem to have been any successful ones.

Thu, 12/11/2014 - 07:45

bkoep 89 941

Offline

Joined: 11/15/2012

Groups: Foldit Staff

Slow and steady

We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.