puzzle picture
1018b: 65 Residue Symmetric Trimer Design
Status: Closed

Summary

Name: 1018b: 65 Residue Symmetric Trimer Design
Status: Closed
Created: 11/25/2014
Points: 100
Expired: 12/02/2014 - 23:00
Difficulty: Intermediate
Description: It's been a long time since our last Symmetric Design puzzle, and Foldit has seen a lot of improvements in the mean time! This puzzle uses two "Core Existence" filters. One checks that the monomer unit of your design contains a well-packed core, and another ensures that the entire symmetric complex has a buried core. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Comments

johnmitch's picture
User offline. Last seen 32 min 38 sec ago. Offline
Joined: 12/28/2010
Groups: None
original 1018 puzzle not found

the original puzzle 1018 in not on the puzzle list. how will people get their solutions into 1018B?

jflat06's picture
User offline. Last seen 19 hours 1 min ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

You can access your old saves from the new puzzle's load-save dialog.

You can also access the old puzzle by clicking show expired puzzles in the puzzle list menu.

Joined: 10/30/2012
Groups: Beta Folders
wondering if more flexibility

wondering if more flexibility was allowed in how the monomers were fit together might allow us a greater range of choices.

so symmetry at the monomer level flexibility at the
complex level

this might allow us to move on from ending up with close packed helixes

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons