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New Foldit paper published!

Today the journal PLOS Biology published a new paper about the work of Foldit players!

The paper describes results from recent Cryo-EM Density puzzles, in which Foldit players folded a protein into a cloud of density. The solutions from Foldit players were better than models produced by expert EM microscopists or automated computer programs!

Check out the blog for more details and a discussion about these exciting results!

(Tue, 11/12/2019 - 20:10  |  1 comment)

Foldit Lab Report #2: Symmetric Design Tips

Happy Fall! Check out Foldit Lab Report #2 on YouTube now!

- Foldit has a new community liaison
- macOS update broke Foldit (but we fixed it)
- New opinion poll about data sharing

- IL-7R binders
- Aflatoxin enzymes
- Symmetry, symmetry, symmetry

- New genes are on their way to the lab

- bkoep shows what makes a designed interface look good

(Fri, 11/01/2019 - 02:00  |  10 comments)

Developer Preview Release Soon

Hey all,

We're about to release an update to the developer preview with some small fixes and changes.

* Added a function GetSymCount - Return the number of symmetry copies. 0 if there are no copies.
* The AddBetweenSegments function has changed to account for symmetric bands:
- (integer segmentIndex1, integer segmentIndex2, [integer atomIndex1], [integer atomIndex2], [integer symnr2])
- Add a band between the two segments. By default bands to the backbone. Specify an atom number from 0 to structure.GetAtomCount() to band to a different atom. (0 for the default backbone atom) Returns band number. Specify an symnr from 0 to structure.GetSymCount() to band to segmentIndex2 of a symmetric copy. Thanks to Timo for these changes!

* Fixed a problem with the linux version using too new of a glibc, causing it to not work on older machines.
* Fixed various threading issues that may have been causing crashes.

(Mon, 10/21/2019 - 21:39  |  8 comments)

Introducing: Foldit Lab Reports!

We're excited to introduce Foldit Lab Reports, a monthly video series with bkoep and others on the Foldit team!

The purpose of this series is to share more with Foldit players about what happens behind the scenes of Foldit. The videos are meant to provide brief, informal summaries of recent activity in Foldit and in the lab. Although they may not be as informative and detailed as some of our blog posts, we hope they will stimulate more discussion, and we encourage players to ask questions and leave comments on the website!

Check out Foldit Lab Report #1 on YouTube now!

- The Foldit team is growing!

- Symmetric protein design with smaller interfaces
- Final rounds for IL-7R binder design

- Promising lab results for symmetric homo-dimers
- Baker Lab scientists adapt Foldit designs for hetero-dimer project

- The Aflatoxin Challenge returns

(Tue, 10/01/2019 - 16:00  |  20 comments)

Aflatoxin Challenge returns!

Help us redesign an enzyme to degrade aflatoxin, a dangerous carcinogen that contaminates much of the world's food supply! After an interval of lab testing by the Siegel Lab at UC Davis, we're back with a brand new strategy for breaking down aflatoxin, and we need Foldit players' help!

Check out the blog for an update on the project, and play the latest puzzle Aflatoxin Challenge: Round 13 now!

(Mon, 09/30/2019 - 23:14  |  1 comment)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons