DeepMind CASP results
We plan to discuss this in more detail once these CASP 14 results are published, but this is a very exciting result that hopefully advances the field of protein structure determination (which was always the ultimate goal of structure prediction).
Many of you who have been here since Foldit's participation in CASP 11 have noticed how our focus has shifted from structure prediction and refinement, to fitting electron density and protein design. This has been particularly evident this year with all your coronavirus efforts.
It is not yet clear how DeepMind's methods will perform with protein design, but the Rosetta community has already incorporated AlphaFold's methods from CASP 13 and we plan to integrate these into Foldit soon.
Lastly, we want to congratulate all of you as DeepMind's co-founder and CEO revealed that Foldit was an inspiration for AlphaFold! Today they gave the keynote talk at the CASP meeting, with an entire slide about Foldit.
Keep up the great folding and keep inspiring everyone!(Fri, 12/04/2020 - 21:09 | 3 comments)
Newsletter November 27: Thanks!
Be sure to take a look at our latest Newsletter! As it says, we are all so thankful for our players--thank you for all of your hard work this year!
Additionally, if you would like to sign up for our mailing list to receive these newsletters, please click here!(Fri, 12/04/2020 - 02:11 | 0 comments)
Lab Report #15: A new kind of puzzle
A couple software updates — big and small — with a whole suite of new features, plus we've got new puzzles for coronavirus and beyond! Watch our latest lab report on YouTube now.
- MERS-CoV binder design
- NEW Designable linker puzzles
Big Announcements for the New Year
Hey folders! The Foldit team is happy to announce an awesome update for you!
Early next year, we will be rolling out a brand new website! This website will have loads of new features that we hope will help players share ideas with each other and help our scientists share more cool science updates with you! Additionally, this change will come with a big clean-up from some of our old systems, which will make development much smoother moving forward and take care of a few bugs which have been sitting around for years. In particular:
When the new website is rolled out, we will remove support for GUI and Lua V1 recipes.
This means that you will no longer be able to write or run GUI and Lua V1 recipes. In preparation for this change, we ask that you convert your recipes into Lua V2 recipes so that they will not be lost in the transition. For V1 to V2 conversions, Foldit player Rav3n_pl has made a converter script, available for Windows users here. For GUI to V2 conversions, we encourage you to ask questions in the #recipes channel of the official Foldit Discord. As we begin this transition, more conversion resources may become available, so following the #recipes channel will be the best way to stay up-to-date. These resources will also be posted to the Foldit Wiki, and we encourage you to use our wiki for all documentation. If you need additional help converting a recipe, please contact us directly at email@example.com with a link to the recipe you'd like converted. It may take us some time, but we will make sure that we get you a Lua V2 version of the recipe.
Why are we getting rid of these systems? Supporting GUI and Lua V1 has always been tricky for us ever since Lua V2 came out. By switching to only one system, we will be able to make new Lua functions and other game features much more quickly, as well as better prevent and eliminate recipe-related bugs. This switch also allows us to roll out the new website much quicker if we only need to support one recipe system.
Thank you so much for your patience and understanding as we work on creating new features for you to enjoy. Your contributions to scientific research are very much appreciated, and we look forward to sharing new science updates soon.
As always, happy folding.(Mon, 11/23/2020 - 17:24 | 4 comments)
We've just released an update with the following fixes:
* Fixed a crash on puzzle load caused by the ContactMS metric.
* Fixed an issue with the DDG metric score behaving oddly in proteins with cutpoints.
Thanks to our devprev players for helping test this release!(Sat, 11/21/2020 - 01:37 | 0 comments)