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New puzzle series: Poly-proline helix

We're introducing a new series of Foldit puzzles, based on a special type of protein structure called a poly-proline helix. We're challenging Foldit players to design new proteins that incorporate this special helix!

Read more on the Foldit blog, and play Puzzle 1763: Poly-Proline Helix Design: Round 1 online now!

(Fri, 11/22/2019 - 00:29  |  2 comments)

New Update

Hey all,

We've just released an update with the following fixes and changes:

Scripts:
* Added a function GetSymCount - Return the number of symmetry copies. 0 if there are no copies.
* The AddBetweenSegments function has changed to account for symmetric bands:
- (integer segmentIndex1, integer segmentIndex2, [integer atomIndex1], [integer atomIndex2], [integer symnr2])
- Add a band between the two segments. By default bands to the backbone. Specify an atom number from 0 to structure.GetAtomCount() to band to a different atom. (0 for the default backbone atom) Returns band number. Specify an symnr from 0 to structure.GetSymCount() to band to segmentIndex2 of a symmetric copy. Thanks to Timo for these changes!

Fixes:
* Fixed a problem with the linux version using too new of a glibc, causing it to not work on older machines.
* Fixed various threading issues that may have been causing crashes.

Note that our 32-bit mac client is deprecated on account of mac discontinuing 32-bit support, so you'll want to switch over to the new 64-bit version if you haven't already.

Thanks to our devprev players for helping test this release!

(Wed, 11/20/2019 - 23:13  |  0 comments)

New Foldit paper published!

Today the journal PLOS Biology published a new paper about the work of Foldit players!

The paper describes results from recent Cryo-EM Density puzzles, in which Foldit players folded a protein into a cloud of density. The solutions from Foldit players were better than models produced by expert EM microscopists or automated computer programs!

Check out the blog for more details and a discussion about these exciting results!

(Tue, 11/12/2019 - 20:10  |  1 comment)

Foldit Lab Report #2: Symmetric Design Tips

Happy Fall! Check out Foldit Lab Report #2 on YouTube now!

NEWS
- Foldit has a new community liaison
- macOS update broke Foldit (but we fixed it)
- New opinion poll about data sharing

PUZZLE UPDATES
- IL-7R binders
- Aflatoxin enzymes
- Symmetry, symmetry, symmetry

LAB UPDATE
- New genes are on their way to the lab

DESIGN TIPS!
- bkoep shows what makes a designed interface look good

(Fri, 11/01/2019 - 02:00  |  10 comments)

Developer Preview Release Soon

Hey all,

We're about to release an update to the developer preview with some small fixes and changes.

Scripts:
* Added a function GetSymCount - Return the number of symmetry copies. 0 if there are no copies.
* The AddBetweenSegments function has changed to account for symmetric bands:
- (integer segmentIndex1, integer segmentIndex2, [integer atomIndex1], [integer atomIndex2], [integer symnr2])
- Add a band between the two segments. By default bands to the backbone. Specify an atom number from 0 to structure.GetAtomCount() to band to a different atom. (0 for the default backbone atom) Returns band number. Specify an symnr from 0 to structure.GetSymCount() to band to segmentIndex2 of a symmetric copy. Thanks to Timo for these changes!

Fixes:
* Fixed a problem with the linux version using too new of a glibc, causing it to not work on older machines.
* Fixed various threading issues that may have been causing crashes.

(Mon, 10/21/2019 - 21:39  |  8 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons