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257: Core and Tail Design 3
Expires: 02/13/10
Top Group: Contenders
Top Player: Mark-
Top Score: 9,650
The last set of solutions for this series was promising, so we're interested to see what happens with this setup. The core has been changed to Alanine for you to mutate. The loops are still locked, but this time there is no inserting allowed! Constraints are holding the backbone near where it starts out, so focus on the sidechains.

223: Core and Tail Design 2
Expired: 11/20/09
Top Group: Richard Dawkins Foundation
Top Player: aap
Top Score: 9,635
Similar to the previous puzzle in this series, this protein has had its core changed to Alanine for you to mutate. The loops are still locked, but this time there is no inserting allowed! Constraints are holding the backbone near where it starts out, so focus on the sidechains.

187: More Core Design
Expired: 08/19/09
Top Group: Richard Dawkins Foundation
Top Player: aap
Top Score: 10,158
Similar to the previous More Core Design, the core of this protein is designable and Alanine. Focus on the core sidechains in this puzzle!

178: Core and Tail Design
Expired: 08/03/09
Top Group: Richard Dawkins Foundation
Top Player: Aotearoa
Top Score: 10,350
Here's another protein that has been changed to Alanine with a core for you to mutate. But there's a small twist: some of the loops are locked, and you insert up to 4 new segments in front of segment 1! Constraints are holding the backbone near where it starts out, so focus on the sidechains. Go into note mode for more information!

174: More Core Design
Expired: 07/29/09
Top Group: Richard Dawkins Foundation
Top Player: aap
Top Score: 11,401
This protein has been changed entirely to Alanine, but the core can be mutated. Can you design a better core?

172: Folding for renewable energy
Expired: 07/26/09
Top Group: Another Hour Another Point
Top Player: g_s
Top Score: 10,041
Xylanase is an enzyme which degrades linear polysaccharides into xylose thus breaking down cellulose. It is found in cellulose digesting bacteria. The degradation of cellulose holds much promise in the field of renewable energy sources. A greater understanding of this system might lead to the discovery new bio-fuels.