Latest Foldit paper named "Article of the month" by Nature Structural & Molecular Biology
The recent Nature Structural & Molecular Biology Foldit paper is their "Article of the month" which also means everyone has Free Access to the paper on the Nature website:
Just click on the *FREE ACCESS* button and you can read the paper, download the full size images and the Supplemental Material (at the bottom).
Congrats everyone!( Posted by beta_helix 140 3184 | Fri, 10/14/2011 - 19:33 | 2 comments )
New Player Statistics
Again, welcome to all the new players that have recently joined Foldit and thank you to all the veteran Foldit players who have been helping everybody out!
It seems like the swell of new players has slowly gone down. Some players were asking how big that wave of new users was, so we wanted to show you the stats:
and you can compare these numbers to last month:
We also want to let all the new players know that even when you are not playing Foldit you can still help us fold proteins to fight diseases by installing Rosetta@home:
By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. We often post Rosetta models outputted from Rosetta@home as Foldit puzzles.
Link to the new Foldit Nature article
We posted the just published NSMB paper. here it is:
This is the second Nature paper we published with Foldit discoveries. This is truly amazing accomplishment. All Foldit players should be proud.
We also have two more in the pipeline one of the algorithmic discoveries in Foldit recipes, and a brand new synthetic protein discovered primarily due to the insight of Foldit protein design. Stay tuned.( Posted by zoran 140 3989 | Sun, 09/18/2011 - 20:44 | 0 comments )
Nature Structural & Molecular Biology paper online!
Welcome to all the new players. Click here to get started: http://fold.it/portal/node/988864
As many of you already know, a protein causing AIDS in rhesus monkeys
that hadn't been solved for 15 years was resolved by Foldit players
and confirmed by x-ray crystallography. That paper was selected for an
Advance Online Publication (AOP) today in Nature Structural &
Molecular Biology; link to paper: http://dx.doi.org/10.1038/nsmb.2119
The crystal structure will be released to the Protein Data Bank soon:
We are so proud of everything that you Foldit players have
accomplished already, and we hope that this article will show the
world the power of citizen science! This is the first instance we are
aware of in which online gamers solved a longstanding scientific
problem and we want to thank you all for your amazing work on this and
everything else. Speaking of which, we are submitting another paper
this week comparing your recipes against the state of the art
H2N2 Flu Design Puzzle Update
The designed small protein binder against H2 Hemagglutinin results are being analyzed right now and the results are very impressive. We are using the top models as design guides to help us understand the differences between binding to H1 and H2 Hemagglutinin. We’ve known for sometime that this design will bind H1 Hemagglutinin (found on the most common strains of the flu and also Spanish flu) but we are trying to extend the design to also bind H2 Hemagglutinin. While the H2 strain of flu is less common today, it was responsible for ~1 million deaths in a 1957 and was last seen in humans in 1968. As your body’s immune system has probably not been exposed to the H2 strain, it would likely not have antibodies that could protect against it, making H2 influenza a potential pandemic should it reappear. By designing a binder to both H1 and H2 strains we are trying to protect against both current and future Influenza threats.( Posted by Aaron Chevalier 140 6839 | Wed, 09/07/2011 - 22:05 | 3 comments )