Official CASP results and Exciting Upcoming Puzzle
We just got back from the CASP9 meeting where the organizers and assessors released all the results.
Foldit was group 170 and you can see the results for the non-refinement categories here:
(This shows all the Foldit predictions for only Model 1, which was always the top scoring Foldit prediction for each puzzle. It only shows a few CASP targets at a time, you have to click on "T0575 - T0604" at the top to see those results, for example)
The results for all 5 submitted Foldit models is here:
All the results for the Refinement category are here:
You can see that Foldit got the best (closest to the native solved structure) predictions for 2 Refinement targets:
which corresponds to CASP9 Refinement Puzzle 8 & CASP9 Refinement Puzzle 10 respectively.
We will post more details about this (as well as how close Foldit players got to the native in the University Folding Challenge, since we all saw who got the highest score!) soon, but we wanted to let you know about the webpage for those of you who want to dig through all the results.
Thanks to Madde's CASP page, you can see who submitted each of the 5 Foldit models for each target: http://de.foldit.wikia.com/wiki/CASP#CASP9-Puzzles
ALSO WE WANTED TO LET YOU KNOW ABOUT AN EXCITING UPCOMING PUZZLE:
We have a new puzzle that is currently unsolved by protein crystallographers. We have a set of protein models determined by NMR, and these don't currently fit perfectly with the X-ray crystallographic data. We are giving you 10 models as starting structures, and we will test if you can find solutions that fit the crystal data better. We'll post more details about the problem and its broad scientific importance when the puzzle is released.( Posted by beta_helix 141 3402 | Wed, 12/15/2010 - 23:04 | 3 comments )
University Challenge: post discussion
Now that the university challenge is completed, we have also found out that the top score of the university-only grand prize competition can be surpassed by Foldit players in just 3 days.
I'm interested in your feedback on the Grand Challenge competition specifically with respect to determining the parameters of any further challenge competition of that sort. Obviously making sure that everyone is included in the competition should be a must. But what about the prizes? My thought was that just cash is likely not a good prize format, but perhaps a donation to the charity of choice for the winning team? Or a paid trip to visit the Foldit team in Seattle? Or perhaps, making Foldit be strictly voluntary and contain no other prizes is the right thing to do? I welcome your feedback below.( Posted by zoran 141 4789 | Sat, 12/11/2010 - 03:02 | 9 comments )
University Competition Folders vs. Universal Foldit Power
Looking at how the University competition is unfolding (no pun intended), it is clear that there has been some serious competition going between many universities. It became obvious quickly that most of the teams entered are actually doing protein folding for their research. So we got a lot more expert graduate students and post docs, than undergraduates. And they are doing very well.
It would be very interesting for us to discover whether free foldit player expertise can outperform heavily incentivized experts at the identical task. As soon as the University Foldit competition is complete, we will release the same puzzle to all foldit players. Should be fun.( Posted by zoran 141 4789 | Tue, 11/16/2010 - 17:18 | 2 comments )
Recruiting the Foldit players of the future
Last weekend members of the Baker Lab and Foldit team participated in the Life Sciences Research Weekend at Seattle's local Science Museum: the Pacific Science Center.
You can read all about it here:beta_helix 141 3402 | Sat, 11/13/2010 - 09:51 | 0 comments )
Playtest a New RNA Folding Game!
Dear Protein Folders:
An exciting new scientific based game is soon to be released by some of the alums of the Foldit team. EteRNA is using the immense power of gamers to understand life at a cellular level by blending citizen and experimental science into a new on-line experience. You play EteRNA by designing RNAs. Top designs will be continually synthesized in the lab and your score reflects how well your or similar designs fold experimentally:
Foldit players have an immense insight into protein folding. The people behind EteRNA are excited to see what scientific discoveries would be uncovered if that insight was applied to RNA folding. So they've reserved some beta-testing spots just for Foldit members!
To request a beta-testing account, email firstname.lastname@example.org.( Posted by Adrien Treuille 141 7168 | Fri, 11/05/2010 - 22:56 | 1 comment )