What's New
News Feed

New Release!

Hey everyone!

We've just released a new update to the main client. Included is a big rework of the Remix tool, and some other small fixes and features.

General:
* Quicksave slots 1-8 are now available through hotkeys.
* Constraints can be hidden/shown in the view options menu.

Tools:
* Remix: Remix has been significantly reworked. Running Remix will now pop up an interface which allows you to select among a list of options. The tool will also now only modify the selected region, instead of moving the rest of the protein along with it. Pressing the Plus button will allow you to store multiple results in quicksave slots 1-8. A score estimate for each result is displayed in the UI.
* Remix is now available on all puzzles.
* Ramachandran Plot: The minimum size of the panel is now smaller.

Selection Interface:
* The Secondary Structure assignment buttons are now in a "Drawer" in the Selection Interface.

Scripting:
* Updated the scripting interface for the new Remix tool. structure.RemixSelected(start, num) will now store up to num results into your quicksave slots, beginning at start. The function will return the actual number of results inserted.
* save.QuicksaveEmpty(slot) will now return whether or not that quicksave slot is empty.

Bug Fixes:
* Small adjustments to ideality scoring due to a misspelling in the database.
* Fixed a crash on loading ligands.

As always, a big thanks to our devprev players for testing this release!

(Wed, 05/04/2016 - 00:51  |  0 comments)

Drug Design Update: Merk Molecular Force Field

Today we are releasing a new way to wiggle small molecules, the Merk Molecular Force Field (MMFF). This wiggle action uses a different scoring scheme (MMFF) than the current wiggle button. In the current implementation of wiggle, it is possible for the small molecule to “fold” in on itself. With MMFF, this shouldn’t be a problem. MMFF is also very good at optimizing hydrogen bonds and the torsional space of the small molecule. There are some optimization problems that need to be worked out with MMFF (as you can see from the videos), but for now, give it a try and let us know what you think! It should be noted that this is only available through the selection interface, for now.

Here are some comparison videos.
Small molecule with MMFF
Small molecule with Wiggle

In addition to the new wiggle of molecules, there are numerous bug fixes in this release. These include fixes for:

1) When switching menus, custom geometry does not disappear. (changing from design to pulling the molecule around)
2) Game freezes when rotamers are generated
3) Too much output in logs
4) When loop building around the ligand, game crashes
5) Replacing atoms crashes - a lot
6) Selection interface quirks

Enjoy, and please post all your bugs in feedback and suggestions and science questions right here in the thread.

( Posted by  free_radical 108 1772  |  Tue, 05/03/2016 - 19:06  |  10 comments )
0

Developer Preview Release Soon

Hey everyone,

We're about to release another update to the Developer Preview. This update includes some fixes for the previous release, as well as some improvements to the new tools.

General:
* Quicksave slots 1-8 are now available through hotkeys.
* Constraints can be hidden/shown in the view options menu.

Remix Tool:
* Added a quicksave UI. Pressing the Plus button will allow you to store results in quicksave slots 1-8.
* Added a score estimate to the UI. This gives you an idea of how good the result compared to other results, without having to shake.
* The UI has been moved down slightly.

Selection Interface:
* The secondary structure assignment hotkeys are now usable when the SS assignment submenu is open.

Scripting:
* Updated the scripting interface for the new Remix tool. structure.RemixSelected(start, num) will now store up to num results into your quicksave slots, beginning at start. The function will return the actual number of results inserted.
* save.QuicksaveEmpty(slot) will now return whether or not that quicksave slot is empty.

Bug Fixes:
* The Remix Tool should no longer have a large delay on the first run in some puzzles.
* Fixed a bug in ligand loading code that was moving atoms to the origin.

(Mon, 05/02/2016 - 23:11  |  1 comment)

Rama Maps: Learn How to Copy Loops

Learn how to copy loops like a pro using the Rama maps, via our next Community Learning Exchange Video by Susume. Do you have a great tip or trick that helps you with Rama maps? Make a video, let me know, get added to our growing collection of fresh videos!

Watch her first video again if you missed it, and if you are just getting up to speed on this whole Rama map thing, you can start this way.

(Mon, 05/02/2016 - 15:21  |  2 comments)

Rama Map Community Learning Exchange Video Live!

This Community Learning Exchange video presented by Susume, is the first in a series discussing the Ramachandran map recently introduced in Foldit.

Thanks, Susume. Look for a new video on Monday!

(Fri, 04/29/2016 - 15:34  |  5 comments)
Get Started: Download
  Windows    OSX    Linux  
Windows
(XP/Vista/7/8)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe