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Developer Chat: Save the Date!

The Date: 02 December 2014 (Tuesday)
The location: #veteran, IRC (Get help with chat here.)
The Time: 1400-1500 (or so, but the official chat ends after an hour) Pacific
The Time Zone Converter: Right this way!
The Topics: Determined by you! Add your questions to this thread! Please keep in mind we do read all your feedback posts, so no need to duplicate your posts that exist there.

Looking for inspiration? Follow-up on previous topics? Read our previous chats.

(Wed, 11/19/2014 - 16:53  |  1 comment)

New Release!

Hey everyone,

We've just released an update with the following fixes and features:

General:
* ED intro puzzle point threshold adjusted.

Filters:
* Core existence filter now colors the core/boundary/surface of the protein.
* Added a version of the core exist filter that applies to the monomer only in symmetry puzzles.

Also of note in this release - recent changes to Rosetta require us to use more recent build tools on OSX. Unfortunately, these new tools do not support pre-10.7. If you are using 10.6 or earlier, you may want to consider upgrading. These versions are no longer supported by Apple themselves and aren't receiving security updates.

(Thu, 11/13/2014 - 20:30  |  1 comment)

Help us to solve a Vascular endothelial growth factor protein!

Vascular endothelial growth factor (VEGF) is a protein released to trigger new blood vessels to form. This is important in embryonic development and when healing from cuts and damage, but it can also be hijacked by cancer cells to trick the body into providing extra blood vessels (angiogenesis).

Puzzle 1012 comes from the VEGF receptor (type 1). The receptor forms a membrane dimer, with an extracellular part that binds VEGF and an intracellular kinase domain which is responsible for signaling. The extracellular portion consists of seven Immunoglobulin-like (Ig) domains. This puzzle consists of the sequence for domain 6.
Some experimental data has been collected for the VEGF receptor, but it hasn't yet lead to a finished structure. The hope is that if you can help us find near-native solutions then your Foldit predictions can be used to improve the structure. That in turn could lead to a better understanding of angiogenesis and eventually to new anti-cancer treatments.

Please try out the first puzzle for this unsolved protein here .

UPDATE: try out the second puzzle for this unsolved protein here .

( Posted by  beta_helix 123 3943  |  Wed, 11/12/2014 - 20:18  |  0 comments )
2

Puzzle 1011 Issues

HEADS UP: Puzzle 1011 will be closing and we'll be posting a different target today - turns out the target was the same as 1008! Big thanks for the sharp eyes in the community who pointed that out to us. We are sorry for any hassle this may cause you.

(Wed, 11/12/2014 - 19:35  |  0 comments)

Developer Preview Release Soon

Hey everyone,

We're about to release an update to the developer preview with the following fixes and features:

General:
* ED intro puzzle point threshold adjusted.

Filters:
* Core existence filter now colors the core/boundary/surface of the protein.
* Added a version of the core exist filter that applies to the monomer only in symmetry puzzles.

Also of note in this release - recent changes to Rosetta require us to use more recent build tools on OSX. Unfortunately, these new tools do not support pre-10.7. If you are using 10.6 or earlier, you may want to consider upgrading. These versions are no longer supported by Apple themselves and aren't receiving security updates.

(Wed, 11/12/2014 - 19:20  |  0 comments)
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