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Developer Preview Release Soon

Hey everyone,

We're about to push a big update to the developer preview soon with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

(Wed, 10/13/2021 - 01:52  |  2 comments)

New Release

Hey all,

We've just released an update to the Foldit client with the following fixes and changes:

General:
* Updated the help panel.
* Scaled opengl view for high-resolution displays.
* Added an orthographic view option.
* Added structure.IsLockedAll() Lua function.
* The Pick Sidechains tool now selects among buried rotamers.

Localization:
* Added a pseudolocalization language to allow translators to see all translatable strings.
* Update the description for Korean in localization.

Bug Fixes:
* Prevent crash on filter.GetData when no data.
* Correct output in LayerScoreFilter.
* Fixed a bug causing some translations to not appear.
* Fixed crashes related to disulfides.
* Update Electron Density Panel to only contain "Select Cloud" button while in the selection interface.

As always, a big thank you to our devprev players for helping to test this release!

(Fri, 10/08/2021 - 15:05  |  0 comments)

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Missed the latest newsletters? Be sure to check them out here! Click this link to sign-up to get news and information each Friday!

(Tue, 10/05/2021 - 03:09  |  0 comments)

Lab Report #25: Education Mode

Foldit Education Mode spells out the science of proteins. Built for students, teachers, and you!

NEWS
- Education Mode now available from the Foldit puzzle menu

PUZZLE UPDATES
- Protein binder design for TGF-beta, IL-2 receptor, CD47
- Symmetric design puzzles

DESIGN OF THE MONTH
- A binder design for the CD47 target, created by nspc in Puzzle 2043, makes excellent hydrophobic contacts with the CD47 target and does a good job of satisfying buried polar atoms with H-bonds. Take a look for yourself in the October Design of the Month sandbox puzzle.

(Fri, 10/01/2021 - 13:02  |  1 comment)

Temporary server issues

We are currently experiencing a problem with our server that will prevent users from signing from the Foldit application or playing Foldit online.

Update: Everyone should now have normally functioning connections to the server again. Thanks for your patience!

(Thu, 09/30/2021 - 17:12  |  15 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons