Foldit Standalone Quickstart Guide

Licensing and Downloading

  1. Visit https://els.comotion.uw.edu/express_license_technologies/foldit.
  2. Select "Licence" under "Academic License" and fill out your information.
  3. You will receive an email with instructions to access the download page.
  4. Click on a link to select a numbered release of Rosetta (currently 3.7).
  5. Select the "Foldit Standalone" download link for your platform.

Citation

If you use Foldit Standalone in your work, please cite:

Robert Kleffner, Jeff Flatten, Andrew Leaver-Fay, David Baker, Justin B. Siegel, Firas Khatib and Seth Cooper. Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta. Bioinformatics 2017 btx283.

Examples

To load in files, choose the "Import PDB/FASTA" button when the program starts. Then select (at least) a ".pdb" or ".fasta" file. The program determines file types by their extension. Depending on the other files you select, different session features will be enabled. For example, selecting a ".density" file will enable electron density.

Here are a few example setups. For each example, you will need to select all files with the same base filename for import. Here are some example Rosetta Script files: repack_no_design.xml, repack_design.xml (these may take up to a minute or two to complete).

Help and Troubleshooting